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apalutamide will lower the extent or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication which have been CYP3A4 substrates may result in reduce publicity to those medications.Whilst not Specially frequent, some